Sick Sinus Syndrome in HCN 1 - Deficient Mice Running title : Fenske
نویسندگان
چکیده
1 Center for Integrated Protein Science CIPS-M and Zentrum für Pharmaforschung Department Pharmazie, Ludwig Maximilians University, Munich, Germany; Medizinische Klinik und Poliklinik I, Klinikum Großhadern, Ludwig Maximilians University, Munich, Germany; DZHK (German Center for Cardiovascular research), partner site Munich Heart Alliance, Munich, Germany; Max-Planck-Institut für Psychiatrie München, Munich, Germany; School of Physics & Astronomy, University of Manchester, Manchester, United Kingdom *contributed equally
منابع مشابه
Sick sinus syndrome in HCN1-deficient mice.
BACKGROUND Sinus node dysfunction (SND) is a major clinically relevant disease that is associated with sudden cardiac death and requires surgical implantation of electric pacemaker devices. Frequently, SND occurs in heart failure and hypertension, conditions that lead to electric instability of the heart. Although the pathologies of acquired SND have been studied extensively, little is known ab...
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Sinus node inhibitors reduce the heart rate presumably by blocking the pacemaker current If in the cardiac conduction system. This pacemaker current is carried by four hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels. We tested the potential subtype-specificity of the sinus node inhibitors cilobradine, ivabradine, and zatebradine using cloned HCN channels. All three su...
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BACKGROUND The normal cardiac rhythm originates in the sinoatrial (SA) node that anatomically resides in the right atrium. Malfunction of the SA node leads to various forms of arrhythmias that necessitate the implantation of electronic pacemakers. We hypothesized that overexpression of an engineered HCN construct via somatic gene transfer offers a flexible approach for fine-tuning cardiac pacin...
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BACKGROUND Sinus node (SN) dysfunction is observed in some long-QT syndrome (LQTS) patients, but has not been studied as a function of LQTS genotype. LQTS6 involves mutations in the hERG β-subunit MiRP1, which also interacts with hyperpolarization-activated, cyclic nucleotide gated (HCN) channels-the molecular correlate of SN pacemaker current (If ). An LQTS registry search identified a 55-year...
متن کاملBenefits of dual chamber pacing in sick sinus syndrome.
The effects of DDD (fully automatic) and VVI (ventricular demand) pacing modes on exercise tolerance, symptom diary cards, and Holter monitoring were investigated in a randomised double blind crossover study of 16 patients who had had DDD pacemakers implanted because of frequent syncope. Eight patients presented with sick sinus syndrome and, with one exception, retrograde atrioventricular condu...
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تاریخ انتشار 2013